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KMID : 0367320010120020165
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2001 Volume.12 No. 2 p.165 ~ p.178
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STUDY ON THE RELATIONSHIP BETWEEN THE ONTOGENETIC PROCESSES AND PSYCHOPATHOLOGY IN AFTENTION-DEFICIT HYPERACTIVITY DISORDER
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Cho Soo-Churl
Jung Yeoung
Shin Sung-Woong
Hwang Jun-Won
Shin Min-Sup
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Abstract
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In order to elucidate the biological etiology and the relationship between the ontogenesis of serotonin system and psychopathology in ADHD, plasma serotonin (5-hydroxytryptamine, 5-HT) and 5-hydrozyindoleacetic acid (5-HIAA) were measured and the correlation between the plasma levels of 5-HT and 5-HIAA and age were evaluated in 46 ADHD patients and 18 control subjects. The ADHD patients were composed of 16 combined type, 10 inattentive type, and 20 hyperactive-impulsive type and the control subjects were communication disorders.
The results are summarized as follows :
1) There was significant difference in plasma 5-HT levels among combined, inattentive and hyperactive-impulsive and control subjects (ANOVA F=4.33, df 3, 60, p<0,05), and post-hoc test using Scheffe method showed significant difference between the combined type and control group. But, post-hoc tests showed no significant differences between combined and inattentive, combined and hyperactive-impulsive, hyperactive-impulsive and inattentive, hyperactive-impulsive and control and inattentive and control groups.
2) There was no significant differences in plasma 5-HIAA levels among the combined, hyperactive-impulsive, inattentive and control groups (ANOVA F=2.08, df 3, 60, p>0.05).
3) Significant difference in 5-HT level was found between the whole ADHD group (N=46) and the control group (N=18) (T=3.10, df 62, p<0.05). But no significant difference in 5-HIAA level was found between the whole ADHD group and the control group (T=1.90, df 62, p> 0.05) .
4) Plasma 5-HT and 5-HIAA levels showed no significant correlation with TOVA findings (5-HT : omission pearson correlation 0.10, commision 0.23, reaction time 0.01, variability in attention 0.11, all p>0.05, 5-HIAA : omission 0.21, commision 0.15, reaction time 0.09, variability in attention 0.15, all p> 0.05) .
5) Plasma 5-HT and 5-HIAA levels showed no significant correlation with attention, hyperactivity and impulsivity based on DSM-IV criteria.
6) Plasma 5-HT and 5-HIAA levels showed no significant correlation with age both in ADHD and control group.
These findings show that decreased plasma 5-HT level may play a role in the genesis of ADHD, but this finding has no significant correlation with the psychopathology of ADHD. And we could not find any significant differences in ontogenetic processes in 5-HT.
Future studies should be focused on the drug effects, family history and prognosis based on the biochemical subtypes (high and low 5-HT group) .
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KEYWORD
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ADHD, Serotonin, 5-HIAA:Psychopathology
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